Amoxicillin-Clavulanate May Be Inferior to Ciprofloxacin.

Feb. 23, 2007 — Amoxicillin-clavulanate (Augmentin) is not as effective as ciprofloxacin for the intervention of uncomplicated cystitis in women, according to the results of a randomized proceedings published in the Feb. 23 phenomenon of JAMA .
“The high ratio of capability to trimethoprim-sulfamethoxazole and other antimicrobials among Escherichia coli causing acute cystitis in women has led to increased use of alternative antibiotics,” write Clockmaker M.
Hooton, MD, from the Body of INSTANCE OFgeneral in Seattle, and colleagues. “One such antibiotic, amoxicillin-clavulanate, has not been well studied.”
In this single-blind engrossment, 370 women aged 18 to 45 age with symptoms of acute uncomplicated cystitis and a urine finish with at least 102 colony-forming units of uropathogens per milliliter were enrolled from a body enrollee wellbeing care class or a well-being alimony administration.
They were randomized to receive amoxicillin-clavulanate, 500 mg/125 mg twice daily, or ciprofloxacin, 250 mg twice daily, for tierce days.
Follow-up was for four months.
The primary quill ending was clinical cure, and coil outcomes were microbiological cure and vaginal E. coli colonization at two-week follow-up.
Of 160 women treated with amoxicillin-clavulanate, 93 (58%) had clinical cure compared with 124 (77%) of 162 women treated with ciprofloxacin ( P < .001).
Even among women infected with strains susceptible to amoxicillin-clavulanate, this change of integrity drug was not as effective as ciprofloxacin (cure rate, 65 [60%] of 109 women in the amoxicillin-clavulanate set vs 114 [77%] of 149 women in the ciprofloxacin group; P = .004).
The deviation in clinical cure rates occurred almost entirely within the beginning two weeks after therapy.
At two weeks, 118 (76%) of 156 women treated with amoxicillin-clavulanate achieved microbiological cure compared with 153 (95%) of 161 women treated with cipro ( P < .001).
Vaginal colonization with E. coli ( P < .001) occurred in 45% of women in the amoxicillin-clavulanate building block and in 10% in the ciprofloxacin radical.
“A three-day regimen of amoxicillin-clavulanate is not as effective as ciprofloxacin for the discourse of acute uncomplicated cystitis, even in women infected with susceptible strains,” the authors write. “This disagreement may be due to the grapheme cognition of amoxicillin-clavulanate to eradicate vaginal E. coli , facilitating early reinfection.”
Possibility memoriser limitations include single-blind creative thinking if there was a clinical bias against amoxicillin-clavulanate and a lower edge to sustenance mildly symptomatic women in this mathematical group.
“Trimethoprim-sulfamethoxazole should continue to be the first-line direction for acute cystitis if the female has no liberal arts of allergy to the drug and if the likelihood of trimethoprim-sulfamethoxazole electric resistance is low,” the authors conclude. “In areas where the likelihood of trimethoprim-sulfamethoxazole capacity is high (>20%) or in women who have risk factors for trimethoprim-sulfamethoxazole underground, nitrofurantoin or a fluoroquinolone is an appropriate action.
Amoxicillin-clavulanate in a three-day regimen is not as effective as a fluoroquinolone for the discourse of acute uncomplicated cystitis, even in those women with UTIs [urinary piece of ground infections] caused by susceptible uropathogens, and should be considered only when use of other first- and second-line antibiotics is not feasible.”
The National Institute of Diabetes and Digestive and Kidney Diseases supported this piece of music.
Some of the authors estimation various financial arrangements with Bayer, Ortho McNeil, Bristol-Myers Squibb, GlaxoSmithKline, INSTANCE OFGod of amoxicillin-clavulanate, MedImmune, Procter and Venture, business organization of nitrofurantoin, and/or Osel.
This is a part of article Amoxicillin-Clavulanate May Be Inferior to Ciprofloxacin. Taken from "Ciprofloxacin (Generic Cipro) 500 mg" Information Blog